Keywords

• BILE EXTRACT PORCINE
• bilebovinedriedunfractionated
• GALBIFFEX R

Quick Details

• ProName: Bile, extract
• CasNo: 8008-63-7
• Molecular Formula: C24H40O5
• Appearance: Yellow-green powder
• Application: Bovine gallbladder clear liver and cle...
• DeliveryTime: 3-7
• PackAge: Bucket/bag
• Port: Tianjin Newport/Qingdao Port
• ProductionCapacity: 100000 Metric Ton/Year
• Purity: 99%
• Storage: Enclosed, cool, dry place
• Transportation: By air/sea
• LimitNum: 1 Kilogram

Superiority

Hebei Tecxiang Chemical Co., Ltd. is an enterprise specializing in the research and development, production and trade of pharmaceutical intermediates, apis and chemical raw materials and formula technology. Our company has extensive experience in the synthesis of organic molecules ranging from milligrams to hundreds of kilograms, and specializes in customized synthesis, synthesis research, manufacturing and production services for pharmaceutical and research and development companies to produce pharmaceutical intermediates and fine chemicals. Our company maintains close cooperation with well-known pharmaceutical enterprises at home and abroad, and has the right to import and export. Our research and development products are mainly sold to well-known pharmaceutical companies at home and abroad, and won the praise of customers.

The company covers an area of 33,616 square meters. At present, the company's total construction area of 24,392 square meters, fixed assets of 60.78 million yuan, the annual actual production of ethylene oxide derivatives 60,000 tons, including medical intermediates and excipients 10,000 tons, green surfactants 50,000 tons. The annual sales revenue exceeds 300 million yuan. There are 76 employees, including 24 professional and technical personnel. It has been identified as a "high-tech enterprise" by the Torch Center of the Ministry of Science and Technology, a "small and medium-sized technology-based enterprise" by the Department of Science and Technology of Hebei Province, and an "enterprise above scale" by the Ministry of Finance. Has obtained 15 practical technology and soft patent technology, and enjoy 6 years of national exclusive chemical generic drug production policy protection.

Details

Quillaja saponin extracts are known to reduce plasma cholesterol levels in humans. Here we study the mechanism of this effect with Quillaja Dry saponin extract (QD). In vitro model of triglyceride lipolysis is used to quantify the effect of QD on the solubilization of cholesterol and of the lipolysis products (fatty acids and monoglycerides) in the dietary mixed micelles (DMM). We found that QD extract decreases significantly both the cholesterol (from 80% to 20%) and saturated fatty acids (SFA, from 70% to 10%) solubilised in DMM. Series of dedicated experiments prove that QD may act by two mechanisms: (1) direct precipitation of cholesterol and (2) displacement of cholesterol from the DMM. Both mechanisms lead to increased cholesterol precipitation and, thus, render cholesterol bio-inaccessible. We prove also that the saponin molecules are not the active component of QD, because highly purified Quillaja extract with very similar saponin composition does not exhibit cholesterol-lowering or SFA-lowering effect. The effect of QD extract on cholesterol solubilisation is most probably caused by the high-molecular weight polyphenol molecules, present in this extract. The reduced SFA solubilisation is caused by Ca(2+) ions of relatively high concentration (1.25 wt%), also present in QD extract, which precipitate the fatty acids into calcium soaps.